The Cards are a terrific pass defense team and should test the red hot Matt Ryan led Falcons' O, but unfortunately Arizona isn't bringing that level of play on the other side of the ball (I bet big in fantasy on Carson Palmer and he's been a total bust) against this, you can put Atlanta's woes on defence. It all points to a shoot out which is why the total is so high.
In terms of the spread, it may come down to who gets the ground game going. Freeman will share time with Tevin Coleman against a pretty stiff stop unit and the Cardinals will try to get David Johnson rolling against a Falcons run defense that has struggled: he could be in for a huge game.
I'll take the points.
Pick: Cardinals +4.5 @ 1.92
Pick: Over 50.5 @ 1.95