*source

and yet, so long in coming...

I'm gonna chuck an idea out here, and say that you were lying, like Cath does?

Prove me wrong, and back up your post with evidence, by all means.

You are sexist Cath.You also need to learn the difference between there and their.

whippet - splendid effort using big words.

Source please?

Sib you bafoon how am I lying you idiot, It's out there in your face.

Night

Nasty stuff this, spreading lies to scare people and then abusing them for questioning them.

sibaroni 07 Jul 01:27


Friend of mine has had it along with 2 of the people he shares a house with (student house), in Sheffield. Said it is not nice, like flu. Recovered now, of course.

Lies,Liese and more lies.

Source Please?

LOL night

Source please? I could give you his name if you like, in fact f*ck it, Richard Dugdale, Sheffiled Uni. Him and two of hs mates. Called me because he was told on Monday what he had, and his tenancy was up on Tuesday. He is in dispute with his landlord, but had to phone him up and say that he couldn't leave on Tuesday as agreed as the doctor had told him to stay at home. The landlord more or less said "tough sh*t". I sorted it out for him, not that it was hard.

sibaroni 07 Jul 01:24
whippet - splendid effort using big words.

Source please?


All off the top of my head actually, unlike the copy and paste merchant over there. I could probably dig up some sources if you were interested. This is one of the few things I actually remember from medicinal chemistry lectures.

Neuraminidase is an enzyme that allows the flu virus to be released from the host cell (called budding). This is how it spreads. However the drug tamiflu is a Neuraminidase inhibitor so it binds to the Neuraminidase enyzme inihibiting its mode of action, thus stopping the virus budding meaning that it cant spread.

Neuraminidase enzyme is coded for somewhere in the viral RNA. So it could mutate yes, and become resistant to tamiflu (i.e its active site changes so that the tamiflu molecule can no longer bind in the active site of the enzyme). However, the natural substrate sialic acid, which is cleaved during the budding process, may also not be able to bind to the active site either, therefore the virus can still no longer budd and this is completely useless.

So you see, you can get a mutation but nothing may come of it.

Yes could mutate. However this is not always deadly (like cath is trying to make out). Infact the chance of it becoming resistant to tamiflu is minute (as outlined above). Therefore, nothign to worry about :)

So basically for people to be totally screwed, we need two things to happen. The virus to become very very virulent, and the virus to resist tamiflu. I price up the odds as being 10.0 for it to become very virulent, and 1.0000000000001 that it resists tamiflu.

To conclude, I am not panicing and I shall be sunning myself on a beach somewhere while cath and her fellow daily mail readers drum themselves up into a state of panic.


P.S. Ever realised that the reason these huge death/infection levels are quoted is to A) Sell papers and B) cover themselves in the unlikely event that things do go horribly wrong and C) detract from the other major issues in our country such as having a sh1t government in charge? If the sh1t does hit the fan, the goons in charge will at least be able to say that they warned us. You have to be pretty guillable/stupid to believe everything you are told in the press, and even more brain dead to copy/paste these things you are told in an attempt to pass it off as your own opinion.

On that bombshell, I bid you goodnight.

Sorry i just realised my odds on tamiflu resistance are wrong, getting tired :D I would say the chances are 1 in a few trillion that it resists tamiflu.

They are based on info about typical virus behaviour. More virulent strains are quite common in flu, however how virulent it becomes is pure guess work. It will certainly become more virulent, however it still may not become a big killer, no one really knows. The chances of it resisting tamiflu are very remote, there are no known cases of widespread tamiflu resistance, hence my very high odds of this happening. I am an expert in medicinal chemistry so know a lot of chemistry and biology about these viruses.

Plus, even if it does resist tamiflu, this may actually hinder the ability of the virus to reproduce, as explained earlier. So for the end of the world to occur, 3 things must happen. Very very virulent, resistant to tamiflu, whilst retaining the mode of action of the neuraminidase enyzme. This has no chance of happening, so I will be relaxing whilst people start to panic. :) Night night

um, still awake thanks!

you went to Fillipino High? Now that's a story!

Apparently some woman just rang the BBC saying there was an epidemic on the way. Well, if you're watching, don't worry, there isn't.

I would say the chances are 1 in a few trillion that it resists tamiflu.

utter nonsense, clearly this bogus DR is not as qualified as he brags

PMSL at the other idiots on here have been seduced.

MUGS :D

Go read up about the mechanism of the neuraminidase enzyme and its inhibitors and then come back and tell me there is a big chance of it resisting tamiflu. The chance is non existant m8.

Scientists have established the first case of the new H1N1 influenza strain showing resistance to Tamiflu, the main antiviral flu drug, Danish officials and the manufacturer said on Monday.
It was expected that the strain would at some point show resistance to Tamiflu, Denmark's State Serum Institute said. The patient was now well and no further infection with the resistant virus had been detected.

"It does not constitute a risk to public health and does not cause changes to the recommendations for the use of oseltamivir (Tamiflu)," the institute said in a statement. (Reuters)