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21 May 20
08:17
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Date Joined:
28 Dec 11
Health workers in the UK will be able to be part of a clinical trial involving a drug touted by Donald Trump as a possible way to prevent the coronavirus.
The trial is the first global study to test whether chloroquine or hydroxychloroquine can prevent infection, whereas previous trials have looked at whether they can treat it.
Hospitals in Brighton and Oxford are the first of a planned 25 sites to take part in the trials.
It is part of an investigation led by the Bangkok-based Mahidol Oxford Tropical Medicine Research Unit (MORU), supported by the University of Oxford and health charity Wellcome
More than 40,000 people who work with coronavirus patients in Europe, Africa, Asia and South America will be involved, MORU co-principal investigator Professor Sir Nicholas White said.
"We really do not know if chloroquine or hydroxychloroquine are beneficial or harmful against COVID-19," he said, adding that the trial was the best way to find out.
It comes just days after US President Donald Trump told reporters that he had been taking the unproven anti-malarial drug to ward off the virus, which has killed almost 330,000 people worldwide.
The trial is the first global study to test whether chloroquine or hydroxychloroquine can prevent infection, whereas previous trials have looked at whether they can treat it.
Hospitals in Brighton and Oxford are the first of a planned 25 sites to take part in the trials.
It is part of an investigation led by the Bangkok-based Mahidol Oxford Tropical Medicine Research Unit (MORU), supported by the University of Oxford and health charity Wellcome
More than 40,000 people who work with coronavirus patients in Europe, Africa, Asia and South America will be involved, MORU co-principal investigator Professor Sir Nicholas White said.
"We really do not know if chloroquine or hydroxychloroquine are beneficial or harmful against COVID-19," he said, adding that the trial was the best way to find out.
It comes just days after US President Donald Trump told reporters that he had been taking the unproven anti-malarial drug to ward off the virus, which has killed almost 330,000 people worldwide.
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My vote is Government ministers should trial it first ... there is no evidence it works and it might be harmful ... perhaps some of our believers in the Gov't will come forward to volunteer themselves as guinea pigs instead of the ministers ...
so thats a no from flasher to participate in the scheme ...
brokenshire on sky today he wouldn't take it,
cant get the picture of trigger out of my mind during mad cow disease when del and Rodney were ordering beef stew in nags head and trigger said its fine ive had it. and del boy says, 2 egg and chips MIKE ,
cant get the picture of trigger out of my mind during mad cow disease when del and Rodney were ordering beef stew in nags head and trigger said its fine ive had it. and del boy says, 2 egg and chips MIKE ,
safely taken by millions of people as prep for malaria, also used to treat lupus and figures from italy suggest it acted as pre exposure prophylaxis in lupus sufferers.
in mumbai 10,000 police officers were offered it as prep, 4,500 took it 5,500 refused. 0 covid deaths in the group that took it compared to 9 in those who refused. some of those who took it did contract covid but only had mild symptoms. this isnt a clinical study but suggests one should be carried out.
in mumbai 10,000 police officers were offered it as prep, 4,500 took it 5,500 refused. 0 covid deaths in the group that took it compared to 9 in those who refused. some of those who took it did contract covid but only had mild symptoms. this isnt a clinical study but suggests one should be carried out.
I think it's good to research it, but I'm somewhat wondering about the methodology they intend to use to test in vivo if it prevents infection. Give some people hydroxychloroquine, give others just sugar, and lock them all in with a bunch of corona patients for a few days?
'cuz in vitro the inhibitation is established already I think.
Don't worry edy or jolly, the "experts" on chit chat slagging this off as they know better (as they do with everything done by the Tories, ever, in every area) are I'm sure working on better drug ideas in their mums bedsit.
Stockpiling drugs before the outcome of testing is idiotic.
Compared to Bozza , don looks as fit as a butchers dog ..
edy 21 May 20 11:12
I think it's good to research it, but I'm somewhat wondering about the methodology they intend to use to test in vivo if it prevents infection. Give some people hydroxychloroquine, give others just sugar, and lock them all in with a bunch of corona patients for a few days?
For vaccine trials the methodology is that the two groups carry on same as normal (within the same guidelines as everyone else) and the trial goes on as long as it takes to show a difference. One problem the vaccine trials have is that the more effective the lockdown => the longer it takes for both groups to get enough exposure to the virus => the longer the trial goes on => the longer it takes to get a vaccine (if one is possible)
I think it's good to research it, but I'm somewhat wondering about the methodology they intend to use to test in vivo if it prevents infection. Give some people hydroxychloroquine, give others just sugar, and lock them all in with a bunch of corona patients for a few days?
For vaccine trials the methodology is that the two groups carry on same as normal (within the same guidelines as everyone else) and the trial goes on as long as it takes to show a difference. One problem the vaccine trials have is that the more effective the lockdown => the longer it takes for both groups to get enough exposure to the virus => the longer the trial goes on => the longer it takes to get a vaccine (if one is possible)
This isn't a vaccine it's a drug to combat people who have it. Given one of its uses is as an anti-viral drug, and it prevents inflamation, and this is a virus that causes a lot of damage due to overactive immune responses (and immune response is closeley related to inflamation) it's not at all insane to say it might be useful.
I'm not saying it WILL be useful but to dismiss it out of hand because Trump likes it is just the sad level the left operate on.
I'm not saying it WILL be useful but to dismiss it out of hand because Trump likes it is just the sad level the left operate on.
Given one of its uses is as an anti-viral drug
What virus is it used against?
What virus is it used against?
Thanks, GoBallistic. I read in the meantime on
https://www.independent.co.uk/news/science/hydroxychloroquine-uk-trial-trump-drug-coronavirus-brighton-oxford-a9525456.html
that they will do something similar with this as they do with the vaccine trials you described.
On Thursday, British Health workers in Brighton and Oxford who are in regular contact with Covid-19 patients will be enrolled in the three month programme, which will either give them active versions of the drug, or a placebo.
In Asia, participants in the trial will be given chloroquine or a placebo.
The trial aims to test whether use of the drugs can prevent those exposed to the virus from going on to contract the disease.
https://www.independent.co.uk/news/science/hydroxychloroquine-uk-trial-trump-drug-coronavirus-brighton-oxford-a9525456.html
that they will do something similar with this as they do with the vaccine trials you described.
On Thursday, British Health workers in Brighton and Oxford who are in regular contact with Covid-19 patients will be enrolled in the three month programme, which will either give them active versions of the drug, or a placebo.
In Asia, participants in the trial will be given chloroquine or a placebo.
The trial aims to test whether use of the drugs can prevent those exposed to the virus from going on to contract the disease.
Just as good to have a fu*king lemsip to help you overcome this supposed killer virus.
Maybe next they will sanction the release of a real bioweapon where people actually drop dead in the street because this propaganda has only made them lose control of the narrative through far to many people using common sense to see through the charade called covid 19
Maybe next they will sanction the release of a real bioweapon where people actually drop dead in the street because this propaganda has only made them lose control of the narrative through far to many people using common sense to see through the charade called covid 19
It has failed previous tests,
But now it's being tested on folk that don't have corona, but as we don't have
Antibody test yet that's a bit of a problem.
Still trump has managed to get his mate to stockpile the drug in the uk.
But now it's being tested on folk that don't have corona, but as we don't have
Antibody test yet that's a bit of a problem.
Still trump has managed to get his mate to stockpile the drug in the uk.
donny the previous trials look suspect, it needs to be administered early in conjunction with azithromycin and zinc but studies used it late, on its own or in big doses very late on. it almost looks like the studies were designed to fail. a double blind, placebo controlled trial would be fairer and hopefully definitive, i dont think we have results from one such trial yet.
Thing is: In a disease that will mostly be asymptomatic to mild, how many candidates in early stages do you really have where usage of a drug would be justified?
I assume everyone is aware that Trump has a financial investment in the manufacturer ?
Yes, but it's said to be minimal and I don't think that's the reason for his continued hyping of it. Think he just wanted onto the bangwagon/hypetrain early and look like a genius compared to the more cautious experts that disgust him so much.
He doesn't have anything to lose. His supporters won't care one iota if it doesn't work out.
He doesn't have anything to lose. His supporters won't care one iota if it doesn't work out.
May 21, 2020 -- 3:05PM, ----you-have-to-laugh--- wrote:
It has failed previous tests,But now it's being tested on folk that don't have corona, but as we don't haveAntibody test yet that's a bit of a problem. Still trump has managed to get his mate to stockpile the drug in the uk.
But we do have Antibody tests, why post such inaccurate and false info?
Would expect folks posting on such sensitive and important matters would do some basic research.
Please, stop wasting everyone's time and bandwidth, trying not to be rude here.
May 21, 2020 -- 3:53PM, breadnbutter wrote:
May 21, 2020 -- 2:05PM, ----you-have-to-laugh--- wrote:It has failed previous tests,But now it's being tested on folk that don't have corona, but as we don't haveAntibody test yet that's a bit of a problem. Still trump has managed to get his mate to stockpile the drug in the uk.But we do have Antibody tests, why post such inaccurate and false info?Would expect folks posting on such sensitive and important matters would do some basic research. Please, stop wasting everyone's time and bandwidth, trying not to be rude here.
???
He's on my block list, but can see he's posting more rubbish as block doesn't work when others requote it.
I still see my post as factual
Good job he's blocked and advise others to follow
I still see my post as factual
Good job he's blocked and advise others to follow
If it’s in any way helpful Govts around the world will many questions to answer.
It’s cheap, available and has a good record.
It’s cheap, available and has a good record.
Jollyswagman
If that's the case then where is the test result that states that?
There is a trial taking place, results awaited.
If that's the case then where is the test result that states that?
There is a trial taking place, results awaited.
UK has not stockpiled the drug as such,rather it was banned from export early in year, embargo on its movement to prevent stockpiling imo.
The situation right now is we don't have anything to use if this virus goes nasty and numbers go up significantly, being ventilated is not a good option,remdisivir appears to be a non starter or at least for the masses.
We need options and fast, we'll before winter. Telling everyone not to take chloraQ for political reasons is silly, hopefully further testing will prove helpful and determine if its got a use in fight against covid19.
The health systems can't cope, the doctors and scientists don't have the answers yet and unlikely many will be arsed popping thar head above the parapet.
Easy answer is get fit, eat well, stay healthy but would expect a healthy society to look after the old and sick .... It can't even do this,but just keep clapping, or else.
The situation right now is we don't have anything to use if this virus goes nasty and numbers go up significantly, being ventilated is not a good option,remdisivir appears to be a non starter or at least for the masses.
We need options and fast, we'll before winter. Telling everyone not to take chloraQ for political reasons is silly, hopefully further testing will prove helpful and determine if its got a use in fight against covid19.
The health systems can't cope, the doctors and scientists don't have the answers yet and unlikely many will be arsed popping thar head above the parapet.
Easy answer is get fit, eat well, stay healthy but would expect a healthy society to look after the old and sick .... It can't even do this,but just keep clapping, or else.
Trump news has just started using it but it's old news in the states really, he was banging on about it 6 weeks ago before proper studies had been done, the trials they subsequently did showed no real benefit and for some it's harmful.
May 21, 2020 -- 4:15PM, duffy wrote:
Trump news has just started using it but it's old news in the states really, he was banging on about it 6 weeks ago before proper studies had been done, the trials they subsequently did showed no real benefit and for some it's harmful.
Correct.
Trump has stated he will shortly cease taking the drug
Abdominal or stomach pain
blistering, peeling, or loosening of the skin
bloody or cloudy urine
bloody, black, or tarry stools
body aches or pain
burning while urinating
chest pain
chills
congestion
cough increased
cough producing mucus
dark urine
difficult or labored breathing
difficult or painful urination
dizziness
drowsiness
dryness or soreness of the throat
earache
fainting
fast, irregular, pounding, or racing heartbeat or pulse
general feeling of discomfort or illness
general feeling of tiredness or weakness
headache
indigestion
irregular or slow heart rate
itching or rash
joint or muscle pain
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
light-colored stools
loss of appetite
muscle aches and pains
nausea or vomiting
noisy breathing
passing of gas
red skin lesions, often with a purple center
red, irritated eyes
redness or swelling in the ear
runny nose
shivering
sneezing
sores, ulcers, or white spots on the lips or in the mouth
stomach pain, continuing
stomach pain, fullness, or discomfort
stuffy nose
sweating
swelling of the face, ankles, hands, feet, or lower legs
tender, swollen glands in the neck
tightness in the chest
trouble with sleeping
trouble with swallowing
unpleasant breath odor
unusual bleeding or bruising
unusual tiredness or weakness
upper right abdominal or stomach pain
voice changes
vomiting of blood
yellow eyes or skin
These are some of the side effects....
blistering, peeling, or loosening of the skin
bloody or cloudy urine
bloody, black, or tarry stools
body aches or pain
burning while urinating
chest pain
chills
congestion
cough increased
cough producing mucus
dark urine
difficult or labored breathing
difficult or painful urination
dizziness
drowsiness
dryness or soreness of the throat
earache
fainting
fast, irregular, pounding, or racing heartbeat or pulse
general feeling of discomfort or illness
general feeling of tiredness or weakness
headache
indigestion
irregular or slow heart rate
itching or rash
joint or muscle pain
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
light-colored stools
loss of appetite
muscle aches and pains
nausea or vomiting
noisy breathing
passing of gas
red skin lesions, often with a purple center
red, irritated eyes
redness or swelling in the ear
runny nose
shivering
sneezing
sores, ulcers, or white spots on the lips or in the mouth
stomach pain, continuing
stomach pain, fullness, or discomfort
stuffy nose
sweating
swelling of the face, ankles, hands, feet, or lower legs
tender, swollen glands in the neck
tightness in the chest
trouble with sleeping
trouble with swallowing
unpleasant breath odor
unusual bleeding or bruising
unusual tiredness or weakness
upper right abdominal or stomach pain
voice changes
vomiting of blood
yellow eyes or skin
These are some of the side effects....
All the government are interested in is money . They love Roche , Glaxo and all the other major drug companies . They are a reactive government rather than proactive .
They have all the data , all the research yet have no idea how to interpret it . Or do they ?
The link between the dead and d deficiency is blatantly obvious to anyone with even minimum scientific knowledge .
There are plenty of experts who recognise this but they chose to listen to the ones who don't .
Tragic .
They have all the data , all the research yet have no idea how to interpret it . Or do they ?
The link between the dead and d deficiency is blatantly obvious to anyone with even minimum scientific knowledge .
There are plenty of experts who recognise this but they chose to listen to the ones who don't .
Tragic .
----you-have-to-laugh--- • May 21, 2020 4:03 PM BST
Jollyswagman
If that's the case then where is the test result that states that?
There is a trial taking place, results awaited.
sorry donny, i dont follow, the 'test results that state that?'
Jollyswagman
If that's the case then where is the test result that states that?
There is a trial taking place, results awaited.
sorry donny, i dont follow, the 'test results that state that?'
well you made a claim
so where are the test results to back up the claim?
so where are the test results to back up the claim?
i think it is worth a genuine trial.
https://www.youtube.com/watch?v=EZG64p0RBDI - from about nine minutes for twenty minutes he discusses hydroxychloroquine, how studies have been conducted and how he thinks they should be conducted.
https://www.youtube.com/watch?v=EZG64p0RBDI - from about nine minutes for twenty minutes he discusses hydroxychloroquine, how studies have been conducted and how he thinks they should be conducted.
The symptoms I listed were for the antibiotic Azithromycin, everyone all over HyydroxychQ but the antibiotic carries a fair list that's strangely ignored by the usual suspects.
Surprised noone is asking why these two drugs Come to be paired and why.
Surprised noone is asking why these two drugs Come to be paired and why.
donny the man called this a pandemic in late january, he discusses the hql trials and their limitations in that show and how he thinks they should be conducted. i dont understand your antipathy as all i am saying that it should be examined in a double blind placebo controlled trial.
here is a study (not yet peer reviewed) that provides in vivo evidence that zinc sulphate in combination with hydroxychloroquine may play a role in therapeutic management for COVID-19.
https://www.medrxiv.org/content/10.1101/2020.05.02.20080036v1.full.pdf
here is a study (not yet peer reviewed) that provides in vivo evidence that zinc sulphate in combination with hydroxychloroquine may play a role in therapeutic management for COVID-19.
https://www.medrxiv.org/content/10.1101/2020.05.02.20080036v1.full.pdf
I have already stated a test/ trial should be carried out.
It is being carried out and we will get results.
In absence of results there is no proof.
There are are many snake oil salesmen mixed in with
innovative scientists who crack problems.
I seem to remember vince cable being hailed a genius for seeing the banks failing,
But he failed to offer proper guidance out of the mire when in
Government.
There are lots of promising ideas.... and data readily available around corona
which has already shown up some odd trends, which in itself holds
out hope that something will be found to help combat the virus
I would be delighted if it turns out to be hydroxychloroquine but
until it does then it remains a theory.
It is being carried out and we will get results.
In absence of results there is no proof.
There are are many snake oil salesmen mixed in with
innovative scientists who crack problems.
I seem to remember vince cable being hailed a genius for seeing the banks failing,
But he failed to offer proper guidance out of the mire when in
Government.
There are lots of promising ideas.... and data readily available around corona
which has already shown up some odd trends, which in itself holds
out hope that something will be found to help combat the virus
I would be delighted if it turns out to be hydroxychloroquine but
until it does then it remains a theory.
Washington Post...
A study of 96,000 patients shows that those treated with hydroxychloriquine or the closely related drug chloroquine were also more likely to suffer irregular heart rhythms that can lead to sudden cardiac death.
By Ariana Eunjung Cha and Laurie McGinley2 hours ago
Interpretation
We were unable to confirm a benefit of hydroxychloroquine or chloroquine, when used alone or with a macrolide, on in-hospital outcomes for COVID-19. Each of these drug regimens was associated with decreased in-hospital survival and an increased frequency of ventricular arrhythmias when used for treatment of COVID-19.
A study of 96,000 patients shows that those treated with hydroxychloriquine or the closely related drug chloroquine were also more likely to suffer irregular heart rhythms that can lead to sudden cardiac death.
By Ariana Eunjung Cha and Laurie McGinley2 hours ago
Interpretation
We were unable to confirm a benefit of hydroxychloroquine or chloroquine, when used alone or with a macrolide, on in-hospital outcomes for COVID-19. Each of these drug regimens was associated with decreased in-hospital survival and an increased frequency of ventricular arrhythmias when used for treatment of COVID-19.
That "study" is being rubbished by various experts as deeply flawed. One suggests in milions of doses of HydxYchQ for maleria prevention and cure there is zero evidence of cardiac death.
But keep it up, you may convince yourself, dollars to donuts you would take it if you were on deaths door, but your trying to prevent others having the option, a horrible horrible thing to do and all because of political bias, sicko.
But keep it up, you may convince yourself, dollars to donuts you would take it if you were on deaths door, but your trying to prevent others having the option, a horrible horrible thing to do and all because of political bias, sicko.
https://townhall.com/columnists/dere****er/2020/05/21/liberals-would-rather-...
Hmm, link no worky, story on here, sums it up well
https://townhall.com
https://townhall.com
A medication that weakens the heart. In an effort to fight malaria, this virus weakens the heart too. Snuff said.
A medication that weakens the heart. In an effort to fight malaria, this virus weakens the heart too. Snuff said.
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