Question for on course layers

Can you settle an issue between a mate and me please....

Is it still possible to get fractions on bets? And (especially with the larger bets), would this apply at Cheltenham? For instance, if 4/1 is generally available on the boards for Binocular in the CH, would a layer accept a £12k to win £50k bet? Would they accept the same odds at lower stakes or would it not be worth the hassle?

Thanks