Sep 12, 2021 -- 3:08PM, Giuseppe wrote:
johny i am wary about the vaccinewho knows what it is doing to our immune systemthe vast majority don't need itjust let them get infected
Not sure where “the” vaccine comes from, because we’ve used two, mainly, and others more than that. They aren’t even terribly similar.
We know very well what the vaccines do to our immune systems. Is your concern that there’s not much long term follow up data because they’re quite new? Only this is true but vaccine side effects are seen early, not late. The vaccine itself doesn’t last terribly long and the immune response peaks fairly early. Which is where waning comes from.
Sep 12, 2021 -- 5:21PM, Giuseppe wrote:
are there any vaccines that people take twice yearly over a long term?it may even be 4 or 5 month top ups
No. We won’t be doing that with the Covid vaccines either. There are, however, plenty of vaccines that need 3 shots and some that need more.
There’s nothing that unexpected about the 3w gap Pfizer dose approach resulting in waning immunity. I mean, we knew months ago that antibody levels dropped off from loads of studies and this is completely what you’d expect anyway. Natural immunity to other Coronaviruses isn’t v long lived either but people exposed before don’t get very unwell, other than extremely rarely.
This is endemicity approaching.
Sep 12, 2021 -- 7:48PM, Giuseppe wrote:
"No. We won’t be doing that with the Covid vaccines either."that's a brace prediction. i hope you're right. i suppose only time will tell.
I thought you meant brace too, on initially reading it. As in brace, brace.
Anyway, I don’t think it’s that brave. I understand how immunity works. I mean, I’m sure Pfizer and others wouldn’t object to selling billions of Covid vaccinations year after year for decades but the projections for the next couple of years include vaccinating low and medium income countries. High income countries will want to be as safe as they can and there may be further boosters, especially for those who used the short initial dosing interval but it’s vanishingly unlikely it will be anything like every 6 months, even for the vulnerable. To be honest, it’s impossible to predict with any degree of certainty beyond that though, because the data are so limited.
Having said that, PHE has just released some data on their estimates of waning. Unlike other studies, they have AZ waning a bit faster than Pfizer. Seems to be much less of an issue in younger people than over 65s but more uncertainty in the numbers there because relatively few younger people were fully vaccinated 6 months back.
Anyway, having been a bit of a booster sceptic before, I’d be wanting a third dose of Pfizer if I were over 70 and especially if I were over 80 and had my second dose in January or a first Pfizer if I’d had AZ and was over 70.